منابع مشابه
Chiral Auxiliaries in Asymmetric Synthesis
Background The use of chiral auxiliaries in the synthesis of enantiomerically pure compounds has found wide application for a variety of reactions over the last three decades. Despite the extensive developments in this area by many academic and industrial research groups, new auxiliary controlled reactions continue to evolve frequently [1]. First objectives in this area have been to develop chi...
متن کاملAbsolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides.
Reaction of the chiral crystals of the achiral amides with n-butyllithium in toluene at -80 degrees C gave optically active alcohols in 17-84% ee.
متن کاملLewis Acid Enabled Copper-Catalyzed Asymmetric Synthesis of Chiral β-Substituted Amides
Here we report that readily available silyl- and boron-based Lewis acids in combination with chiral copper catalysts are able to overcome the reactivity issues of unactivated enamides, known as the least reactive carboxylic acid derivatives, toward alkylation with organomagnesium reagents. Allowing unequaled chemo-reactivity and stereocontrol in catalytic asymmetric conjugate addition to enamid...
متن کاملApplication of chiral sulfoxides in asymmetric synthesis
Over the last three decades, the sulfinyl group has received considerable attention in asymmetric synthesis1‒5 as a chiral tool. The sulfinyl group is widely used as to bring about numerous asymmetric transformations. The effectiveness of the sulfoxide in diastereoselective auxiliary-induced reactions is mainly due to the steric and stereo electronic differences existing between the substituent...
متن کاملAsymmetric synthesis mediated by chiral ligands
Chiral chelated lithium amides were designed and synthesized. Studies have been done to explore the use of these lithium amides or their corresponding amines for enantioselective reactions such as deprotonation of prochiral cyclic ketones, kinetic resolution of racemic 2-substituted cyclohexanones by deprotonation, regioselective deprotonation of optically active 3-keto steroids, alkylation of ...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1992
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac199264121849